Change Horses
A racing game with a twist.
Players secretly get a horse (of a particular color) assigned before the game starts. The player with the horse in last place at the end of the game wins.
On your turn - sequence of play is decided by auction - you play a card that controls two different colored horese. When every player has put down cards, the horses move; but only horses with an odd number of cards on the table! If the number of open cards is even, the horse does not move.
But, true to the spirit of horse racing, each player has a chance to play a "dirty trick", including Change Horses. This can affect the game dramatically.
The best detailed description of the game is here.
{This is one of the few multiplayer games that plays equally well with only two}